ISSN 1662-4009 (online)

ey0015.1-4 | New mechanisms | ESPEYB15

1.4 Disrupted-in-Schizophrenia-1 is essential for normal hypothalamic-pituitary-interrenal (HPI) axis function

H Eachus , C Bright , VT Cunliffe , M Placzek , JD Wood , PJ Watt

To read the full abstract: Hum Mol Genet 2017;26:1992-2005Mutations in human DISC1 have been previously associated with mental illness, such as schizophrenia and depression. Moreover, DISC1 has been shown to be important in regulating CNS neurogenesis through the Wnt/β-catenin pathway. However the mechanism by which DISC1 causes mental illness is not known. In this elegant work, Eachus <...